Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance

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Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance

OBJECTIVE The peptide hormone adropin regulates fuel selection preferences in skeletal muscle under fed and fasted conditions. Here, we investigated whether adropin treatment can ameliorate the dysregulation of fuel substrate metabolism, and improve aspects of glucose homeostasis in diet-induced obesity (DIO) with insulin resistance. METHODS DIO C57BL/6 mice maintained on a 60% kcal fat diet ...

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Effects of Eight Weeks of Resistance Training and High-Intensity Interval Training on Adropin, Blood Glucose Markers, Insulin Resistance, and Body Composition of Overweight and Obese Females

Background and objectives: Previous investigations have shown that physical activity can improve insulin sensitivity and body composition by reducing the concentration of inflammatory biomarkers. The study aimed at evaluating effects of eight weeks of resistance training and high-intensity interval training on adropin, blood glucose markers, and body composition in overweight females. Methods:...

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ژورنال

عنوان ژورنال: Molecular Metabolism

سال: 2015

ISSN: 2212-8778

DOI: 10.1016/j.molmet.2015.01.005